ISSN: 1899-0967
Polish Journal of Radiology
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2019
vol. 84
 
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Musculoskeletal radiology
Original paper

Assessment of 3-T MRI using susceptibility-weighted imaging to detect and evaluate intra- or periarticular blood metabolites and meniscal tears of the knee

Dominik A. Sieron
,
Dionysios Drakopoulos
,
Milena Mitrakovic
,
Marek Tombarkiewicz
,
Daniel Knap
,
Ivan Platzek
,
Maciej Tomalski
,
Andreas Christe

© Pol J Radiol 2019; 84: e340-e346
Online publish date: 2019/09/06
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Introduction

In recent years, magnetic resonance imaging (MRI) of the knee joint has been declared as the most sensitive and specific noninvasive method for evaluation of meniscal tears [5, 6]. The routine protocol for evaluation of the knee entities includes conventional spin-echo T1-weighted image (T1WI), fast spin-echo proton density-weighted, and gradient-echo. The most used sequence for the meniscal inspection is a fast (or turbo) spin-echo, intermediate-weighted fat-suppressed sequence.
Susceptibility-weighted imaging (SWI) is now available on commercial MR scanners and is used widely in brain imaging. This sequence takes advantage of the difference in the magnetic susceptibilities of tissues, achieving a new type of contrast that differs from those obtained with conventional T1- and T2-weighted MR imaging [9]. SWI is extremely sensitive to changes of susceptibility and enhances the contrast between tissues with different susceptibilities. Studies that focus on its use in the knee-joint are lacking. SWI is by definition sensitive to paramagnetic susceptibility effects, in particular blood, calcification, haemosiderin, and slow flow in vascular structures [10]. Therefore, SWI is a potentially useful imaging tool in the demonstration of menisci, cartilage, subchondral bone, ligaments, and muscles. The aim of the present study was to compare SWI and pre-existing MRI techniques for detection of lesions, haemorrhage, and meniscal tear, particularly T1WI and proton density-weighted imaging.

Material and methods

Data acquisition

During the period from January to August 2017 we prospectively collected all posttraumatic cases of routine knee MRI in our institute. Inclusion criteria were the following: all patients who suffered a knee trauma of any kind, regardless of whether the cause was from a direct trauma or a rotatory accident. We included all age groups that were sent to us for assessment of post-traumatic consequences such as bone bruise, torn ligament, or meniscal tear. Exclusion criteria were the following: Patients with indication for knee MRI other than trauma, e.g. inflammation, infection, postoperative, rheumatoid arthritis, and bursitis. The MRI was performed on an Achieva MRI 3 Tesla unit (Philips, Amsterdam, Netherlands). For this continuously acquired representative population, we added an additional SWI transversal sequence, as a basic source, to the standard routine knee MRI protocol. VSWI, the 3D reconstructions based on the SWI transversal sequence, allowed calculation of the coronal and sagittal images. The entire MRI study consisted of a 26-minute protocol, with parameters shown in Table 1.
No contrast media was administered. Institutional Review Board (IRB) approval was waived due to the implementation of a well-established SWI clinical sequence into the clinical routine protocol.

Ground truth

Acquired MR images of knee joints were analysed by two radiologists with seven and 10 years of experience in musculoskeletal MRI imaging. For the ground truth, both readers had to agree on the signal intensity independently.

Study

Two additional general radiologists, with seven and three years of experience in musculoskeletal MRI imaging, reviewed the images in consensus for signal intensities.
The readout was performed on a GE-workstation (General Electric, Milwaukee, Wisconsin, USA) for two anatomical regions: 1) meniscus was analysed separately; and 2) the rest of the articular joint space including all ligaments (cruciate, collateral, patellar, and femoropatellar ligaments), synovia, capsule, and periarticular soft tissue.
All readers were blinded to the diagnosis and had to score the signal intensity on T1, proton density (PD), and SWI sequences for both anatomical regions separately. T1 and PD hyperintensity and SWI hypointensity in both regions were recorded and equalled positivity for haemorrhage. Any signal change (hyper- or hypointense) in any sequence was classified as positivity for any pathology (see Statistics below).

Statistics

A general lesion was defined as any pathology/variant with either PD, T1, or SWI hyper- or hypointensity. Haemorrhage in the periarticular space was defined as any lesion with either T1 hyperintensity or SWI hypointensity, without conspicuous PD-hypointensity (calcification). Meniscal haemorrhage was defined as T1 hyperintensity and SWI hypointensity, without conspicuous PD-hypointensity (calcification) (Figure 1).
Any signal change in any acquisition plane was defined as hyper- or hypointensity for the whole sequence. For the ground truth, both readers had to agree on positivity independently.
Sensitivity, specificity, and accuracy for haemorrhage and any lesion were calculated for T1, PD, and SWI, respectively, using the reader’s detection rate against the ground truth. To compare significant differences of the sequences, Fisher’s exact test was applied using MedCalc® version 7.6.0.0 (MedCalc Software, Mariakerke, Belgium). A significance level of p < 0.05 was utilised.

Results

A total of 63 patients were included (F : M = 22 : 41). The median age of the cohort was 29 years (range 13 to 71 years). Thirty-nine patients showed a meniscal tear, and only three of them (7.7%) demonstrated a meniscal haemorrhage (Figure 1). A total of 18 patients suffered from a periarticular injury, and 16 patients (88.9%) demonstrated a concomitant periarticular haemorrhage (Figures 2 and 3).

Periarticular joint space

SWI demonstrates best sensitivity for detection of haemorrhage in the periarticular joint space: Sensitivity for T1, PD, and SWI was 25.0, 62.5, and 100%, respectively (SWI vs. T1: p < 0.0001 and SWI vs. PD: p = 0.018). All three sequences scored specificities > 95%, leading to the following accuracies for T1, PD, and SWI: 81.0, 87.3, and 96.8%, respectively (SWI vs. T1: p = 0.009). SWI also showed the best results for any lesion detection in the (peri)articular joint space: accuracy for T1, PD, and SWI was 77.8, 90.2, and 93.7%, respectively (SWI vs. T1: p = 0.02 and SWI vs. PD: p = 0.086). Sensitivity of T1 to detect any lesion in the periarticular joint space was significantly lower for T1 (22.2%) than that for PD (66.7%, p = 0.018) and SWI (88.9%, p < 0.0001) (Tables 2 and 3).

Meniscus

Haemorrhage in the meniscus was best scored on SWI (p < 0.0001).
Accuracies for T1, PD, and SWI were 42.9, 34.9, and 98.4%, respectively. While all sequences depicted meniscal haemorrhage (100%), only SWI maintained a high specificity of 98.4%; T1 and PD specificity dropped to 40% and 31.7%, respectively.
Furthermore, while SWI demonstrated a remarkable detection rate for haemorrhage and other lesions in the periarticular joint space, it demonstrated the lowest score for any meniscus lesions (Figure 3).
PD demonstrated the best accuracies for diagnosis of any lesion in the meniscus. The accuracy results for T1, PD, and SWI were 82.5, 90.5, and 44.4%, respectively (Figure 2). The SWI accuracy was significantly lower than that of T1 and PD (p < 0.0001) (Tables 4 and 5).

Discussion

The purpose of our research was to apply SWI sequences in post-traumatic patients and to image blood components and their quantity within the structures of articular cavity and periarticular area of the knee joint. The study revealed great specificity and sensitivity of SWI sequences in assessing blood metabolites; however, it did not reveal an increased sensitivity in assessing post-traumatic changes within intra-articular structures, such as the ligament apparatus, especially the cruciate ligament and within the meniscus, in comparison with that of the standard protocol used in the T1, T2, and PD imaging sequences [11, 13, 17]. As we know, MRI studies are performed in standard protocols without DWI because of the poor sensitivity and specificity for meniscal lesions and ACL trauma [1, 2, 15, 18].
SWI protocol is a fairly new protocol that is successfully applied in neurology but not in orthopaedics. SWI is used during routine brain diagnostics, e.g. in diagnosing and assessing intracranial brain haemorrhage or calcification or in assessing the image of cerebral veins in the case of an increase in the deoxyhaemoglobin level [5, 6, 14].
Magnetic resonance has become the routine examination in assessing knee joint structures as a diagnostic examination and often as an examination that precedes surgery planning [7, 8, 9, 12]. In fact, this is the reason why the assessment of quantity of blood metabolites within the knee joint, in the case of patients with chronic injury, may have clinical significance in terms of the influence of intra-articular microcalcification on the articular surface of the knee joint and possible microtrauma. During MRI examination performed soon after an injury, intra-articular fluid and fresh blood are often visible. During medical check-up, often performed after 4-6 weeks due to the waiting time for a medical procedure, blood and its metabolites are no longer visible with standard sequences.
Blood metabolites were also invisible in basic sequences within soft tissues in the knee joint area. Such metabolites, observed in imaging, may directly affect patients’ complaints.
Among available articles, only one study describes the application of the SWI protocol for assessing structures within the knee, such as meniscal structures [4]. In our view, the SWI protocol is not very sensitive and specific and makes it possible to overlook smaller changes in comparison with that for standard T1, T2, and PD sequences. The SWI protocol does not allow accurate assessment of the course of meniscal structure injury, which is essential in planning for arthroscopic surgery [4].
The SWI protocol does not exhibit appropriate sensitivity or specificity in diagnosing ACL injury. In our study, we did not obtain positive images of ACL injury when compared with those from standard MRI sequences [3]. We also did not visualise blood metabolites within injured ACL tendons.
Arthroscopic surgery of the knee joint is a gold standard in assessing intra-articular structures; however, routine examinations to date, such as MRI, constitute a diagnostic routine and may often have an influence on the decision concerning patient’s surgery, which is reflected in the patient’s quality of life and has an economic and diagnostic impact [16, 17]. An experienced physician is able to assess meniscal or ligament apparatus injury based on clinical examination just as well as via diagnostic imaging. However, physicians are unable to determine the quality and quantity of blood metabolites within the knee joint before and after surgery, which may have an influence on microtrauma of articular cartilage of the knee joint.
We are aware that when examining patients’ knee joints using MRI, the SWI sequence is not fundamental. However, the SWI sequence allows us to obtain additional information, which we have previously described, within the cartilage. The sequence also allows the detection of possible venous malformations, intra-articular haemorrhage, early degenerative changes of calcific nature, or venous malformations.

Conclusions

SWI can be used to diagnose intra- and periarticular blood metabolic detection, but its sequence fails to detect meniscal tears according to the present study.

Ethical standards and informed consent

Ethical approval (IRB) and informed consent were waived due to the retrospective nature of the study with irreversible anonymisation of patient identifiers.

Conflict of interest

The authors declare no conflict of interest.

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Copyright: © Polish Medical Society of Radiology This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
 
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