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1/2022
vol. 87 Cardiovascular radiology
abstract:
Original paper
Computed tomography independent quantitative determinants of CAD-RADS 4 versus CAD-RADS 3 for calcified coronary lesions
Amal Abdelsattar Sakrana
,
Heba M. Abou El Atta
,
Goda Mohammad
,
Dalia Bayoumi
© Pol J Radiol 2022; 87: e606-e612
Online publish date: 2022/11/08
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Introduction
An investigation of coronary computed tomography angiography (CCTA)-derived quantitative parameters to determine CAD-RADS 4 versus CAD-RADS 3 of coronary lesions with moderate to severe calcification. Material and methods The study included 150 coronary lesions proven to have moderate or severe stenosis by invasive coronary angiography and showing moderate to severe calcification in CCTA. Various CCTA-quantitative parameters were correlated to the degree of stenosis (moderately versus severely stenosed lesions). Their sensitivity and specificity to detect severe stenosis (supposed to be corresponding to CAD-RADS 4) were examined at multiple cut-off points. Results The calcification remodelling index (CRI) was the only statistically significant independent computed tomography angiography-derived predictor of severe stenosis versus moderate stenosis on multivariate regression analysis. The best cut-off value was ≤ 0.84, with 77.78% sensitivity and 86.46% specificity. Conclusions From all quantitative-derived CCTA parameters, CRI ≤ 0.84 was the predictor with the highest diagnostic performance for severe versus moderate stenosis in moderately to severely calcified coronary lesions. Accordingly, CRI can help to determine CAD-RADS 4 versus CAD-RADS 3. keywords:
coronary stenosis, coronary CT angiography, coronary calcification, calcified coronary lesions, calcified plaques, CAD-RADS |