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Polish Journal of Radiology
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vol. 83
Original paper

Penile Doppler ultrasonography and elastography evaluation in patients with erectile dysfunction

Namik Kemal Altinbas
Nurullah Hamidi

© Pol J Radiol 2018; 83: e491-e499
Online publish date: 2018/12/03
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Erectile dysfunction (ED) or impotence is characterised by persistent inability to develop and maintain an erection of the penis in men for intercourse [1]. ED is one of the most common sexual disorders in males, and it affects about half of the male population between 40 and 70 years old [2,3]. ED is a neurovascular phenomenon modulated by hormonal, local biochemical, and biomechanical factors [4-7]. Erectile dysfunction may signal serious underlying diseases, such as hypertension [2], diabetes mellitus [8,9], cardiovascular disease [10,11], peripheral vascular disease [12], and other endocrine [13] and neurological disorders [14,15].
Penile Doppler US provides real-time evaluation of cavernosal vascular flow dynamics. Colour and spectral penile Doppler ultrasonography (US) is a highly accurate tool for assessing patients with erectile dysfunction [16,17] and it has been used for diagnostic purposes since its first application in 1985 [18]. However, it has been reported that penile Doppler US might not give accurate results in diagnosis of venous insufficiency in some cases [19,20]. During the procedure, many patients also suffer from pain during papaverine injection. Moreover, priapism can develop in a minority of the patients who undergo penile Doppler US [21]. Because penile Doppler US does not seem to be a perfect test, we aimed to improve the diagnosis by adding sonoelastography, and tried to find out if elastography had any positive effects on diagnosis of ED.
As a relatively new sonographic method, elastography is currently under investigation for tissue characterisation of several anatomic sites. More recently, elastography has been used in urology practice for evaluation of the stiffness of the cavernous body of the penis [22,23]. Elastography is a completely non-invasive procedure different from penile Doppler US, and it provides additional information to the information obtained in penile Doppler US by the examination of the tissue stiffness.
Our objective was to evaluate the relationship between erection grade, erectile function score, Doppler US indexes, and elasticity score (ES) according to Doppler US diagnosis in patients with ED.

Material and methods

Study group

This study was performed as a prospective study in the Department of Radiology between April 2016 and April 2017. All patients gave written, informed consent for sonographic evaluation and for this study. All procedures were performed in accordance with the Declaration of Helsinki for human subjects, and our Institutional Review Board approved the study.
We included patients who had ED complaints referred from urology department to radiology department for penile Doppler US to determine the aetiology of ED. The exclusion criteria were the following: (1) patients who had a history of penile and/or urethral surgery, (2) history of radiotherapy, radical pelvic surgery, (3) medical therapy that might cause ED, (4) neurological, hormonal, and psychological disorders that might cause ED.
A total of 88 patients who met the inclusion criteria were enrolled in the study.


In all patients, urological examinations and consultations were performed by the same clinician, and the procedure of penile Doppler US was indicated. Penile Doppler US was indicated for those patients with ED who did not respond to oral phosphodiesterase type 5 inhibitors.
Sonographic evaluations were performed by the same radiologist, having experience in elastography. Grey-scale US, Doppler US, and elastography examinations were performed with a Logiq S7 Expert machine (GE Healthcare, Milwaukee, WI) equipped with a 9L-D linear-array probe. In the examination room, with the patient lying in a supine position and the penis held in the anatomical position, 2 ml (60 mg) of papaverine was injected with an insulin injection needle into the lateral aspect of the proximal third of the right cavernous body via US guidance under sterile conditions. On grey-scale US, probable lesions such as Peyronie’s plaques were evaluated by dorsal and ventral approach in longitudinal and transverse planes. After the injection, a dynamic assessment of the spectral Doppler waveform in the cavernosal arteries was performed on the proper Doppler angle at 30-60 degrees. Spectral Doppler US findings including peak systolic velocity (PSV) and end-diastolic velocity (EDV) were recorded, and the diagnosis based on Doppler US was determined. Post-injection measurements including PSV, EDV, visual maximum tumescence, and erection hardness were taken from 0 to 20 minutes. This sonographic examination was terminated after spectral Doppler measurements taken at the 20th minute. The patients were warned about probable priapism. If the PSV value was below 25 cm/s during the examination, the diagnosis was arterial insufficiency. When the PSV was ranged from 25 to 30 cm/s, the diagnosis was borderline for arterial insufficiency. PSV values above 30 cm/s were considered normal for arteriogenic function. When a good diastolic reversal or below 5 cm/s EDV values were achieved during the examination, venous insufficiency was ruled out. When the EDV value was still above 5 cm/s at the end of the examination, the diagnosis was venous insufficiency [17,18,24-27]. Penile elastography was performed for all patients during penile Doppler US examination at the 10th-12th minutes for each of the patients to achieve the maximum erection hardness. During the sonographic examination, none of the patients achieved more erection grade than that which we assigned. Slight repetitive manual compressions were performed keeping the transducer perpendicular to the skin during the evaluation of strain type elastography. On the images, region of interest (ROI) selection was placed on the right and left corpus cavernosum using a free-hand drawing tool along each border. ES was obtained as ESR (elasticity score of right corpus cavernosum) and ESL (elasticity score of left corpus cavernosum) by elastographic analysis. ESA (average elasticity score of right and left corpus cavernosum) was calculated. The ES is a semi-quantitative value, and while a low ES indicates soft tissue, a higher ES indicates stiff tissue. When evaluated by colour perspective, while red colour reflects less stiff tissue, blue colour reflects more stiff tissue. Green colour reflects medium stiff tissue of the entire area undergoing elastography. The described strain type elastography method represents relative information about hardness [28-30].

Erection Hardness Grading Scale

The time, which each of the patients achieved the maxi­mum erection hardness, the scoring was graded by the radiologist who performed the examination according to the Erection Hardness Grading Scale (EHGS) during penile Doppler US examination to provide standardisation in scoring. According to the scale: grade 0 represents ‘not enlarged’, grade 1 represents ‘larger but not hard’, grade 2 represents ‘hard but not hard enough for penetration’, grade 3 represents ‘hard enough for penetration but not completely hard’, and grade 4 represents ‘completely hard and fully rigid’ [31].

International Index of Erectile Function and Sexual Health Inventory for Men

The patients were asked five questions about erection confidence, erection hardness, maintenance ability, maintenance frequency, and intercourse satisfaction based on the International Index of Erectile Function (IIEF) questionnaire, and the Sexual Health Inventory for Men (SHIM) level was defined [32,33]. Each participant answered the questionnaire individually, without any help. Maximum effort was made to ensure privacy when the participants were completing the questionnaire. Each IIEF item was scored on a five-point ordinal scale, in which lower values represent poorer sexual function. Possible scores for the IIEF-5 ranged from 5 to 25. Severity of ED was classified into five categories as: severe (IIEF-5 scores; 5-7), moderate (scores; 8-11), mild to moderate (scores; 12-16), mild (scores; 17-21), and no ED (scores; 22-25).

Statistical analysis

Statistical analyses were performed using SPSS software version 15.0 for Windows (IBM Corporation, Armonk, NY). Descriptive statistics of continuous variables are given as mean ± standard deviation (SD) and median (interquartile range). To compare groups, the Mann-Whitney U test was used for non-normally distributed data and Student’s t-test was used for normally distributed data. The degree of association between variables was calculated by Spearman’s correlation coefficient. Differences among the four groups for non-normally distributed variables were evaluated by Kruskal-Wallis variance analysis. When the p-value from the Kruskal-Wallis test statistics was statistically significant, a multiple comparison test was used to determine which group differed from which of the others [34]. Receiver operating characteristic (ROC) curves were used to describe the performance of diagnostic values of ES variables between the normal group (n = 38) and the ED group (borderline for arterial insufficiency, arterial insufficiency, and venous insufficiency) (n = 50) according to Doppler diagnosis. The area under the corresponding curves was calculated as described by Hanley and Mc-Neil [35]. P < 0.05 was considered statistically significant.


There were a total of 88 patients with a mean age of 49.20 ± 14.08 (19-75) years. The erection hardness grade, IIEF-5 score, and SHIM level are shown in Table 1. Peak systolic velocity (PSV), end-diastolic velocity (EDV), elasticity score right (ESR), elasticity score left (ESL), and elasticity score average (ESA) indexes of each group are shown in Table 2. Of the 88 patients, 50 (57%) had abnormal penile Doppler US findings. According to Doppler US findings, patients were classified as normal (n = 38) (Figure 1), borderline for arterial insufficiency (n = 4) (Figure 2), arterial insufficiency (all were diabetic) (n = 5) (Figure 3), and venous insufficiency (n = 41) (Figure 4).
Age of the patients, PSV, EDV, erection hardness grade, IIEF-5 score, SHIM level, ESR, ESL, and ESA indexes were compared among the groups based on the Doppler diagnosis. There were statistically significant differences among the groups, as shown in Table 3.
Peyronie’s plaques were detected in four patients with grey-scale US. In the study group there were accompanying health problems including diabetes mellitus (type 1 and 2), hypertension, hyperlipidaemia, coronary artery disease, peripheral arterial disease, ankylosing spondylitis, scleroderma, old penile trauma, male infertility, varicocelectomy, multiple sclerosis, familial Mediterranean fever, and partial pancreatectomy.
When compared with the normal group, in terms of ES, the arterial failure borderline group and venous failure group had lower scores, and the arterial failure group had a higher score. The only statistically significant difference was obtained for the left corpus cavernosum of the venous failure group (Tables 3 and 4).
When compared with the normal group, in the arterial insufficiency borderline group, EHGS, PSV, and EDV indexes had a statistically significant difference, whereas IIEF-5, SHIM, ESR, ESL, and ESA values did not have any significant difference.
In the arterial insufficiency group, EHGS, IIEF-5, SHIM, PSV, and EDV values had statistically significant differences when compared with the normal group, whereas ESR, ESL, and ESA values did not differ.
When compared with the normal group, in the venous insufficiency group, EHGS, IIEF-5, SHIM, EDV, and ESL indexes had statistically significant differences, whereas PSV, ESR, and ESA values did not have a significant difference.
Erection hardness grade was mostly detected as grade 3 in patients with venous insufficiency, grade 1 and 2 in patients with arterial problems, and grade 4 in normal patients according to Doppler findings. The lowest erection hardness grade and IIEF-5 score were detected in the patients with arterial failure (Table 1).
ROC curves were performed (Figure 5) and area under the curve (AUC) was reported by comparison of the normal (n = 38) and ED group (n = 50) (Table 4). The best cut-off values with sensitivity and specificity were determined between the normal and ED groups. If the cut-off value was taken as less than or equal to 0.95 for ESR, then ED was present with 48% sensitivity and 74% specificity. If the cut-off value was taken as ≤ 1.15 for ESL, then ED was present with 72% sensitivity and 47% specificity. If the cut-off value was taken as ≤ 0.875 for ESA, then ED was present with 38% sensitivity and 82% specificity.
The correlation analysis between erectile function score, Doppler US indexes, and ES according to Doppler US diagnosis was performed. A negative weak correlation was found between IIEF-5 score and EDV (r = –0.421, p < 0.001), and between PSV and EDV (r = –0.240, p = 0.025). A positive strong correlation was found between ESR and ESL (r = 0.824, p < 0.001), ESR and ESA (r = 0.956, p < 0.001), and ESL and ESA (r = 0.948, p < 0.001). The results of correlation analysis between IIEF-5 score and ESA (r = –0.167, p = 0.119), PSV and ESA (r = –0.068, p = 0.527), and EDV and ESA (r = –0.140, p = 0.119) were not statistically significant.
Priapism was observed in two young patients, aged 22 and 31 years, who had normal type penile Doppler US findings according to Doppler results with fully rigid erection.


Penile erection occurs with a complex interaction between neural, arterial, venous, and sinusoidal systems. Any defect in one of these systems can result in ED that is a serious health dilemma affecting both men and their partners.
While Doppler US is a highly preferred method in the evaluation of ED [36], sonoelastography is a new, noninvasive method that promises new findings in this area [37]. Based on this idea, we aimed to evaluate whether sono­elastography has any effect on the diagnosis of ED. Our findings suggested that sonoelastography might provide additional information on the stiffness of the corpus cavernosum of the penis.
As ED can have psychogenic, organic (endocrine disorders, neurogenic, morphological penile abnormalities, and drug-induced), or mixed aetiology [24,36], vascular pathologies categorised as arterial (arteriogenic impotence) or venous (venogenic impotence) insufficiency can cause ED [24,36]. Vasculogenic ED has been shown to be the most common aetiology of organic ED in the literature [36]. Abnormal Doppler outcome (57%) in our study population showed the importance of vascular aetiology in patients with ED complaints in accordance with the literature [38-41]. In addition to this data, we categorised Doppler findings in terms of the Doppler diagnosis as normal (n = 38, 43%), borderline for arterial insufficiency (n = 4, 5%), arterial insufficiency (n = 5, 6%), and venous insufficiency (n = 41, 47%) among the patients with ED, and recorded that the majority of cases had venous Doppler abnormality.
There are some studies in the literature using elastography, including real-time strain sonoelastography or shear wave elastography (SWE), on penile structure and penile mass, such as Peyronie’s plaques [22,42-44]. Stiffness of the penile cavernous body reflects the changes in tissue structure and composition of corpus cavernosum penis, which includes decreased sinusoids, and this results in occlusion and fibrosis [3,22]. Based on the fact that the stiffness of the corpus cavernosum of the penis has an important impact on the erectile function, Zhang et al. evaluated the stiffness of the penile cavernous body with SWE on 40 healthy volunteers and concluded that SWE could serve as a non-invasive method [22]. In a study conducted by Inci et al. the authors drew similar conclusions [44]. Some studies, using sonoelastography on Peyronie’s plaques, reported that sonoelastography provided ad­ditional and useful information in detecting penile le­sions [42,43].
Two recent reports evaluating the ES to obtain data on penile cavernous body stiffness have been published. In the study conducted by Turkay et al. [37] the authors compared two groups, in which ED patients and healthy volunteers were included, using SWE, without performing penile Doppler US and/or papaverine injection. They reported that SWE had high specificity and positive predictive value in the radiological evaluation of ED patients. On the other hand, the obtained cut-off values with strain type elastographic evaluation of ED did not achieve a dia­gnostic level with low sensitivity and specificity in our study. In another study conducted by Zhang et al. [45] the authors used ultrasound vibro-elastography technique to measure the viscoelasticity of the penis in 10 patients with ED or Peyronie’s disease. They performed assessments before and after erectogenic drug injection and reported significant increases in viscoelasticity of the penis after erectogenic injection, validating the ability of the ultrasound vibro-elastography technique to measure dynamic changes in erection.
In our study, we used strain elastography with elasticity scores ranging from an absolute value of zero (softest) to six (hardest). When we compared the groups in terms of elasticity scores, the arterial failure borderline group and the venous failure group had lower scores (less stiff), and the arterial failure group had a higher score (stiffer) than the normal group. A statistically significant difference was recorded only in the left corpus cavernosum of the penis in the venous failure group. This might be because of the papaverine injection with an insulin needle into the right cavernous body via US guidance. Therefore, this significant difference in the left (no needle injection side) cavernous body of the venous failure group might be considered more valuable.
With papaverine injection, priapism can be seen in the patients as a short-term complication. In our study group, priapism was observed in two young patients (2.3%), aged 22 and 31 years, who had normal type penile Doppler US findings according to Doppler results with fully rigid erection. In the literature, Kilic et al. reported that priapism developed in 2.68% of patients in their series who were treated successfully [21]. In our opinion, attention should be paid especially to young patients with fully rigid erection during the penile Doppler examination.
The findings in the study are subject to limitations. First, caution must be applied to the small sample size of arterial insufficiency and borderline for arterial insufficiency groups. The total number in those groups should be increased. The second limitation is the heterogeneity of the study group. All patients were given the same amount of intracavernosal injection, and re-dosing was not performed. Therefore, we might have obtained a higher rate of false positive venous leakage. Other sensitive/specific tools such as arteriography, dynamic infusion cavernosometry, or cavernosography may also be performed to compare the additional benefits of elastography. Future studies, which will evaluate aforementioned comparisons, would be useful.
In conclusion, real-time strain elastography can easily be performed to detect the stiffness of the corpus cavernosum penis accompanied by Doppler US in patients with ED. Our results revealed that ultrasound elastography could provide additional useful information on the stiffness of the cavernous body along with Doppler diagnosis. Therefore, elastography may be performed concomitantly with penile US to obtain data on stiffness of corpus cavernosum penis in routine clinical practice.

Conflict of interest

The authors declare that they have no conflicts of interest.


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