ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
Current issue Archive About the journal Editorial board Abstracting and indexing Contact Instructions for authors
SCImago Journal & Country Rank



2018
vol. 83
 
Share:
Share:
more
 
 
abstract:
Original paper

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (1 HMRS)

Monika Cichocka, Justyna Kozub, Paulina Karcz, Andrzej Urbanik

© Pol J Radiol 2018; 83: e24-e31
Online publish date: 2018/02/04
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Purpose
The aim of this 1HMRS study was to define sex-related differences in metabolic spectrum between healthy children. Forty-nine girls and boys aged 6-15 years were examined.

Material and methods
Volume of interest was located in seven brain regions: frontal lobes, basal ganglia, hippocampi, and cerebellum.

Results
Statistical analysis of the results showed significantly higher (p < 0.05) myo-inositol concentrations relative to the total concentrations in the boys than the girls, as well as higher absolute N-acetyl aspartate concentrations in the left frontal lobes in girls. No other significant differences were shown, except for trends in differences.

Conclusions
In clinical practice the diagnostic process first of all focuses on assessing concentrations of metabolites to relative cerebellum concentration. Thus, the findings of the present study allow the conclusion that when analysing the results of 1HMRS studies in children it is not necessary to take into account the child’s gender.

keywords:

proton magnetic resonance spectroscopy (1HMRS), brain, children, sex differences

references:
Maudsley AA, Govind V, Arheart KL. Associations of age, gender and body mass with 1H MRS observed brain metabolites and tissue distributions. NMR Biomed 2012; 25: 580-593.
Kułak W, Sobaniec W, Śmigielska-Kuzia J et al. Metabolite profile in the basal ganglia of children with cerebral palsy: a proton magnetic resonance spectroscopy study. Developmental Medicine & Child Neurology 2006; 48: 285-289.
Wu WE, Gass A, Glodzik L et al. Whole brain N-acetylaspartate concentration is conserved throughout normal aging. Neurobiol Aging 2012; 33: 2440-2447.
Harris JL, Yeh HW, Swerdlow RH et al. High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol Aging 2014; 35: 1686-1694.
Corrigan NM, Shaw DW, Richards TL et al. Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder. Journal of Autism and Developmental Disorders 2012; 42: 105-115.
ElBeheiry AA, Abougabal AM, Omar TI et al. Role of brain magnetic resonance spectroscopy in the evaluation of suspected mitochondrial diseases in children: Experience in 30 paediatric cases. Egypt J Radiol Nucl Med 2014; 45: 523-533.
Sailasuta N, Ernst T, Chang L. Regional variations and the effects of age and gender on glutamate concentrations in the human brain. Magn Reson Imaging 2008; 26: 667-675.
Santos JMG, Fuentes LJ, Vidal JB et al. Regional effects of age and sex in magnetic resonance spectroscopy. Radiología 2010; 52: 342-350.
Tayoshi S, Sumitani S, Taniguchi K et al. Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS). Schizophr Res 2009; 108: 69-77.
Maudsley AA, Domenig C, Govind V et al. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med 2009; 61: 548-559.
Donia MM, Abougabal AM, Zakaria YM et al. Role of proton magnetic resonance spectroscopy in diagnosis of pilocytic astrocytoma in children. Alexandria Journal of Medicine 2012; 48: 131-137.
Nagae-Poetscher LM, Bonekamp D, Barker PB et al. Asymmetry and gender effect in functionally lateralized cortical regions: A proton MRS imaging study. J Magn Reson Imaging 2004; 19: 27-33.
Cahill L. Why sex matters for neuroscience. Nat Rev Neurosci 2006; 7: 477-484.
Komoroski RA, Heimberg C, Cardwell D et al. Effects of gender and region on proton MRS of normal human brain. J Magn Reson Imaging 1999; 17: 427-433.
Sijens PE, den Heijer T, Origgi D et al. Brain changes with aging: MR spectroscopy at supraventicular plane shows differences between women and men. Radiology 2003; 226: 889-896.
Kułak W, Sobaniec W, Śmigielska-Kuzia J et al. An Age and Gender Dependency of Metabolite Concentrations in Basal Ganglia in Children with Spastic Diplegia: Proton Magnetic Resonance Spectroscopy Study. J Child Neurol 2009; 24: 73-79.
Schweinsburg BC, Alhassoon OM, Taylor MJ et al. Effects of alcoholism and gender on brain metabolism. Am J Psychiatry 2003; 160: 1180-1183.
Pouwels PJW, Frahm T. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med 1998; 39: 53-60.
Ross AJ, Sachdev PS, Wen W, Brodaty H. Longitudinal changes during aging using proton magnetic resonance spectroscopy. J Gerontol A Biol Sci Med Sci 2006; 61: 291-298.
Hadel S, Wirth Ch, Rapp M et al. Effects of age and sex on the concentrations of glutamate and glutamine in the human brain. J Magn Reson Imaging 2013; 38: 1480-1487.
O’Gorman RL, Michels L, Edden RA et al. In vivo detection of GABA and glutamate with MEGA-PRESS: reproducibility and gender effects. J Magn Reson Imaging 2011; 33: 1262-1267.
Chang L, Jiang CS, Ernst T. Effects of age and sex on brain glutamate and other metabolites. Magn Reson Imaging 2009; 27: 142-145.
Weiduschat N, Mao X, Beal MF et al. Sex differences in cerebral energy metabolism in Parkinson’s disease: A phosphorus magnetic resonance spectroscopic imaging study. Parkinsonism Relat Dis 2014; 20: 545-548.
Chang L, Ernst T, Strickland T, Mehringer CM. Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users. Am J Psychiatry 1999; 156: 716-722.
Dickstein DP, van der Veen JW, Knopf L et al. Proton magnetic resonance spectroscopy in youth with severe mood dysregulation. Psychiatry Res 2008; 163: 30-39.
Weber AM, Soreni N, Stanley JA et al. Proton magnetic resonance spectroscopy of prefrontal white matter in psychotropic naïve children and adolescents with obsessive–compulsive disorder. Psychiatry Res 2014; 222: 67-74.
Cichocka M, Kozub J, Karcz P et al. Regional Differences in the Concentrations of Metabolites in the Brain of Healthy Children: A Proton Magnetic Resonance Spectroscopy (1HMRS) Study. Pol J Radiol 2016; 81: 473-477.
 
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe