ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
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1/2022
vol. 87
 
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Urogenital radiology
abstract:
Original paper

Study of renal parenchymal changes by diffusion tensor imaging in diabetic nephropathy

Anish Haladi Panduranga
1
,
Kirti Chaturvedy
1
,
Manish Chaturvedy
2
,
Prateek Sihag
3
,
Girja Nandvanshi
1
,
Sunil Vishnoi
1
,
Abhishek Kaushik
1
,
Asaf Ali Khammar
1

1.
Department of Radiodiagnosis, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India
2.
Department of Nephrology, AIIMS Jodhpur, Rajasthan, India
3.
AIIMS Bilaspur, Himachal Pradesh, India
Pol J Radiol 2022; 87: e163-e171
Online publish date: 2022/03/08
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Purpose
To evaluate differences in diffusion imaging parameters, including fractional anisotropy (FA) and the apparent diffusion coefficient (ADC), in control and diabetic subjects, and to assess changes in these parameters to patient’s urine albumin/protein levels, estimated glomerular filtration rate (eGFR), and glycated haemoglobin (HbA1c).

Material and methods
This is a cross-sectional analytical study involving 100 patients who underwent diffusion imaging including diffusion tensor imaging (DTI) of the kidneys in our hospital from 2019 to 2020. Diffusion imaging parameters (ADC and FA) were obtained from the medulla and cortex of both kidneys using dedicated software. Statistical analysis was done.

Results
Out of 100 subjects, 27 were controls and 73 were diabetics (19 normoalbuminuric, 23 microalbuminuric, and 31 proteinuric). The medullary FA (0.419 ± 0.024 vs. 0.346 ± 0.042), cortical FA (0.194 ± 0.035 vs. 0.303 ± 0.067), and cortical ADC (3.307 ± 0.341 vs. 2.309 ± 0.515) values showed significant differences between controls and diabetics. Medullary FA and cortical ADC values showed a decreasing trend with an increasing amount of albumin/protein in the urine, decreasing renal function (reducing eGFR), and increasing HbA1c, whereas the trend was opposite for cortical FA. In addition, on ROC curve analysis a cut-off value for medullary FA of 0.4 had a sensitivity of 64% and specificity of 80.95% to differentiate healthy volunteers and diabetics with normo-albuminuria.

Conclusions
DTI has the potential to be a promising non-invasive test for the detection of early renal parenchymal changes in diabetic nephropathy.

keywords:

DTI, ADC, diffusion tensor imaging, FA, diabetic nephropathy, renal DTI




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