ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
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1/2020
vol. 85
 
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Gastrointestinal and abdominal radiology
abstract:
Original paper

The relationship between FDG PET/CT-defined metabolic parameters and the histopathological subtype of oesophageal carcinomas

Ulku Korkmaz
1
,
Muhammet Bekir Hacioglu
2
,
Osman Kostek
2
,
Necdet Sut
3
,
Hilmi Kodaz
4
,
Bulent Erdogan
2
,
Funda Ustun
1
,
Mert Saynak
5
,
Ebru Tastekin
6
,
Irfan Cicin
2
,
Gulay Durmus-Altun
1

1.
Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey
2.
Department of Medical Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
3.
Department of Statistics, Faculty of Medicine, Trakya University, Edirne, Turkey
4.
Department of Medical Oncology, Acıbadem Eskişehir Hospital, Eskişehir, Turkey
5.
Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
6.
Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
© Pol J Radiol 2020; 85: e254-e260
Online publish date: 2020/05/15
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Purpose
18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) combined with computed tomo­graphy (CT) scan is accepted as a standard tool in the staging of oesophageal cancer (OC). Histological subtype of tumour is known to be a major determinant of prognosis and metabolic behaviour. In this study, we aimed to evaluate the effect of histological subtypes of OC on standard uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) obtained by PET/CT, and also to compare this effect with prognosis.

Material and methods
Images and clinical course data of 57 patients who were diagnosed with EC and treated in our hospital between 2009 and 2016 were evaluated in a retrospective manner. PET/CT images were re-analysed in terms of metabolic parameters, and observations were compared with histological subtypes.

Results
No significant difference was observed between histological subtypes with SUVmax, overall survival (OS), or progression-free survival (PFS). Thus, MTV was observed to be related with histological subtype; MTV values of adenocancer patients were significantly higher than those of squamous cell cancer patients.

Conclusions
Metabolic tumour volume was related with histological subtype of OC, but clinical staging, TLG, and SUVmax values were not related with histological subtype, which may suggest the use of MTV as a routine parameter for OC and inclusion of MTV observations in prognostic scoring.

keywords:

oesophageal cancer, PET/CT, squamous cell cancer, SUVmax, MTV, TLG

 
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