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1/2019
vol. 84 Head and neck radiology
abstract:
Original paper
Assessment of lacrimal glands in thyroid eye disease with diffusion-weighted magnetic resonance imaging
Ahmed Abdel Razek
,
El-hadidy Mohamed El-Hadidy
,
Mohamed El-Said Moawad
,
Nader El-Metwaly
,
Amr Abd El-hamid El-Said
© Pol J Radiol 2019; 84: e142-e146
Online publish date: 2019/03/08
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Purpose
To assess the lacrimal glands in patients with thyroid eye disease with diffusion-weighted magnetic resonance (MR) imaging. Material and methods This study was carried out on 44 consecutive patients (17 males, 27 females, with mean age 36 years) with thyroid eye disease and 20 age- and sex-matched volunteers. They underwent diffusion-weighted MR imaging of the orbit. The apparent diffusion coefficient (ADC) values of the lacrimal glands were calculated and correlated with the clinical activity score (CAS). Results The mean ADC of lacrimal glands in thyroid eye disease (1.73 × 10–3 mm2/s) was significantly higher (p = 0.001) than that of volunteers (1.52 × 10–3 mm2/s). The cutoff ADC value of lacrimal gland used for differentiation of thyroid eye disease from volunteers was 1.62 × 10–3 mm2/s with an area under the curve value of 0.95 and an accuracy of 96%. There was significant difference (p = 0.03) in the ADC of the lacrimal glands in patients with active (n = 24) and inactive (n = 20) disease. The cutoff ADC value of the lacrimal gland used to suspect active disease was 1.76 × 10–3 mm2/s with an area under the curve value of 0.80 and an accuracy of 82%. There was positive correlation between the ADC value of the lacrimal glands and CAS (r = 0.73, p = 0.001). Conclusions The ADC of the lacrimal glands is a non-invasive imaging parameter that can be used for diagnosis of thyroid eye disease and to predict the active form of the disease. keywords:
diffusion, MR imaging, lacrimal gland, thyroid eye disease |