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1/2022
vol. 87 Interventional radiology
abstract:
Review article
Benefitial role of electrochemotherapy in locally advanced pancreatic cancer – radiological perspective
Oliwia Kozak
1
,
Stanisław Hać
2
,
Joanna Pieńkowska
3
,
Michał Studniarek
1
1.
Department of Radiology, Medical University of Gdansk, Poland
2.
Department of General Endocrine and Transplant Surgery, Medical University of Gdansk, Poland
3.
2nd Department of Radiology, Medical University of Gdansk, Poland
Pol J Radiol 2022; 87: e30-e42
Online publish date: 2022/01/13
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Irreversible electroporation (IRE) of locally advanced pancreatic cancer is an increasingly used method for unresectable pancreatic cancer that can be used in cytoreduction followed by surgical treatment and shows promising results in palliative care.
IRE is an ablative technique where electric pulses cause damage to the cell membrane leading to apoptosis without the destruction of stroma. The application of IRE increases the concentration of hydrophobic regimens like bleomycin within the tumor, what could improve the effectiveness of treatment. This fusion of those two treatments is called electrochemotherapy. In this review, the authors will discuss the radiological perspective of possible beneficial role of irreversible electroporation in relation with chemotherapy in pancreatic cancer treatment. keywords:
irreversible electroporation, pancreatic cancer, tumor ablation |
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