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1/2023
vol. 88 Gastrointestinal and abdominal radiology
abstract:
Original paper
Evaluation of peripheral enhancement on contrast-enhanced computed tomography and corresponding pathological findings in colorectal liver metastases after preoperative chemotherapy
Akio Tamura
1
,
Kazuyuki Ishida
2
,
Misato Sone
1
,
Kunihiro Yoshioka
1
1.
Department of Radiology, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate Prefecture 028-3695, Japan
2.
Department of Diagnostic Pathology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan
© Pol J Radiol 2023; 88: e251-e255
Online publish date: 2023/05/16
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Purpose:
To correlate peripheral enhancement on contrast-enhanced computed tomography (CE-CT) in patients with post-chemotherapy colorectal liver metastases (CRLM) with the corresponding pathological findings. Material and methods: Forty-four patients with CRLM who underwent hepatic resection after preoperative chemotherapy between 2008 and 2013 were included. Two radiologists blinded to the histopathology findings performed a consensus categorization of the marginal contrast effects of CRLM on CE-CT as follows: Group 1, smooth margin without enhancement; Group 2, smooth margin with an enhanced rim; and Group 3, fuzzy margin with/without an enhanced rim. The Kruskal-Wallis test was used to compare the imaging findings with the histological findings. Results: The percentage of infarct-like necrosis was significantly higher in those with CRLM with smooth margins than in those with CRLM with fuzzy margins (p < 0.001, r = 0.62). The percentage of viable cells was lowest in CRLM with smooth margins without enhancement (p < 0.001, r = 0.60). Conclusions: Our findings suggest that the type of necrosis is related to the nature of the margins, and the presence of residual cells is related to peripheral enhancement. keywords:
colorectal liver metastases, CT morphology, bevacizumab, radiopathological correlation |