ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
vol. 88
Gastrointestinal and abdominal radiology
Original paper

Evaluation of peripheral enhancement on contrast-enhanced computed tomography and corresponding pathological findings in colorectal liver metastases after preoperative chemotherapy

Akio Tamura
Kazuyuki Ishida
Misato Sone
Kunihiro Yoshioka

Department of Radiology, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate Prefecture 028-3695, Japan
Department of Diagnostic Pathology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan
© Pol J Radiol 2023; 88: e251-e255
Online publish date: 2023/05/16
View full text Get citation
PlumX metrics:
To correlate peripheral enhancement on contrast-enhanced computed tomography (CE-CT) in patients with post-chemotherapy colorectal liver metastases (CRLM) with the corresponding pathological findings.

Material and methods:
Forty-four patients with CRLM who underwent hepatic resection after preoperative chemotherapy between 2008 and 2013 were included. Two radiologists blinded to the histopathology findings performed a consensus categorization of the marginal contrast effects of CRLM on CE-CT as follows: Group 1, smooth margin without enhancement; Group 2, smooth margin with an enhanced rim; and Group 3, fuzzy margin with/without an enhanced rim. The Kruskal-Wallis test was used to compare the imaging findings with the histological findings.

The percentage of infarct-like necrosis was significantly higher in those with CRLM with smooth margins than in those with CRLM with fuzzy margins (p < 0.001, r = 0.62). The percentage of viable cells was lowest in CRLM with smooth margins without enhancement (p < 0.001, r = 0.60).

Our findings suggest that the type of necrosis is related to the nature of the margins, and the presence of residual cells is related to peripheral enhancement.


colorectal liver metastases, CT morphology, bevacizumab, radiopathological correlation

Quick links
© 2023 Termedia Sp. z o.o.
Developed by Bentus.