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1/2023
vol. 88 Neuroradiology
abstract:
Review paper
Restricted diffusion in benign intracranial neoplasms: a narrative review
Usha Rani Niranjan
1
,
Sunitha Palasamudram Kumaran
1
,
Nayana Nagappa Sriramanakoppa
1
,
Sanjaya Viswamitra
1
1.
Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, India
Pol J Radiol 2023; 88: e494-e505
Online publish date: 2023/10/30
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Diffusion-weighted imaging (DWI) is a valuable diagnostic tool, which provides functional information by exploring the free diffusivity of water molecules into intra- and inter-cellular spaces that in tumours mainly depend on cellularity. It provides information regarding the tumour grade and helps with the diagnosis. Often high-grade tumours show restricted diffusion due to a high degree of cellularity, increased nuclear-to-cytoplasmic ratio, and reduced extracellular space. Benign central nervous system (CNS) tumours rarely show restricted diffusion on magnetic resonance imaging (MRI), and most of them have a characteristic imaging appearance. When benign CNS neoplasms reveal restricted diffusion on MRI, the radiologist is compelled to suggest a malignant neoplasm, making their diagnosis challenging. Knowledge of these exceptions helps to avoid possible errors in diagnosis. We present this integrated review with clinical, radiology-pathological correlation.
keywords:
diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC), benign, intracranial, tumours, restriction |