ISSN: 1899-0967
Polish Journal of Radiology
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vol. 87
Gastrointestinal and abdominal radiology
Original paper

The value of the apparent diffusion coefficient value in the Liver Imaging Reporting and Data System version 2018

Gehad Ahmad Saleh
Ahmed Abdel Khalek Abdel Razek
Lamiaa Galal El-Serougy
Walaa Shabana
Rihame Abd El-Wahab

Department of Diagnostic Radiology, Mansoura University, Faculty of Medicine, Mansoura, Egypt
Department of Tropical Medicine, Mansoura University, Faculty of Medicine, Mansoura, Egypt
Pol J Radiol 2022; 87: e43-e50
Online publish date: 2022/01/17
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To assess role of the apparent diffusion coefficient (ADC) in the Liver Imaging Reporting and Data System (LI-RADS) version 2018 for the prediction of hepatocellular carcinoma (HCC).

Material and methods
Retrospective analysis of 137 hepatic focal lesions in 108 patients at risk of HCC, who underwent magnetic resonance imaging of the liver. Hepatic focal lesions were classified according to LI-RADS-v2018, and ADC of hepatic lesions was calculated by 2 independent blinded reviewers.

The mean ADC of LR-1 and LR-2 were 2.11 ± 0.47 and 2.08 ± 0.47 × 10-3 mm2/s, LR-3 were 1.28 ± 0.12 and 1.36 ± 0.16 × 10-3 mm2/s, LR-4, LR-5 and LR-TIV were 1.07 ± 0.08 and 1.08 ± 0.12 × 10-3 mm2/s and LR-M were 1.02 ± 0.09 and 1.00 ± 0.09 × 10-3 mm2/s by both observers, respectively. There was excellent agreement of both readings for LR-1 and LR-2 (r = 0.988), LR-3 (r = 0.965), LR-4, LR-5 and LR-TIV (r = 0.889) and LR-M (r = 0.883). There was excellent correlation between ADC and LI-RADS-v2018 (r = –0.849 and –0.846). The cut-off ADC used to differentiate LR-3 from LR-4, LR-5, and LR-TIV were ≤ 1.21 and ≤ 1.23 × 10-3 mm2/s with AUC of 0.948 and 0.926.

Inclusion of ADC to LI-RADS-v2018 improves differentiation variable LI-RADS categories and can helps in the prediction of HCC.


liver cancer, hepatocellular carcinoma, abdominal MRI scan, diagnostic imaging

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