ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
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2019
vol. 84
 
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Neuroradiology
abstract:
Review paper

Chemical exchange saturation transfer (CEST) as a new method of signal obtainment in magnetic resonance molecular imaging in clinical and research practice

Anna Pankowska
,
Katarzyna Kochalska
,
Artur Łazorczyk
,
Katarzyna Dyndor
,
Paulina Kozioł
,
Bartosz Zieńczuk
,
Michał Toborek
,
Radosław Pietura

© Pol J Radiol 2019; 84: e147-e152
Online publish date: 2019/03/11
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The work describes the physical basis of the chemical exchange saturation transfer (CEST) technique; it presents the beginnings of the implementation of the method and its possible applications. The principles of correct data acquisition and possible solutions used during the design of the CEST sequence are shown. The main problems related to data analysis are indicated, and an example Z-spectrum from in vivo study of the rat brain is introduced. Furthermore, the parameters related to spectrum analyses such as magnetisation transfer asymmetry (MTRasym) and amide proton transfer asymmetry (APTasym) are presented. In the following part, different types of the CEST method often mentioned in the literature are discussed. Subsequently, the possible applications of the CEST method in both clinical and experimental practice are described.
keywords:

Z-spectrum, molecular imaging, chemical exchange, proton transfer, CEST (chemical exchange saturation transfer), ATP (amide proton transfer)

 
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