Elastography: a surrogate marker of renal allograft fibrosis – quantification by shear-wave technique

Introduction
Renal fibrosis is the most common cause of allograft failure in kidney transplantations. Evaluation of renal abnormalities has progressed considerably over the past years. Currently, the diagnosis of intrarenal fibrosis and quantification of its development with non-invasive assessment tools is possible. This may help in early detection of renal allograft dysfunction. This study sought to assess the efficacy of 2D real-time shear-wave elastography (SWE) in the quantitative measurement of renal allograft dysfunction.

Material and methods
A total of 172 patients were included in our study. SWE was performed in all these patients just before renal allograft biopsy. The cortical elasticity was assessed and described in terms of Young’s modulus (kPa). Banff histopathological grading obtained from transplant kidney tissue biopsy was taken as the reference standard. The potential correlation between SWE scores and Banff classification was performed.

Results
There was a significant correlation between the Banff grade and mean SWE score, with a correlation coefficient of 0.665 (p < 0.001). The individual correlation coefficients of interstitial fibrosis and tubular atrophy with mean SWE score stood at 0.667 and 0.649 respectively (p < 0.001). The correlation of resistive indices was insignificant when compared to mean polar SWE score in respective poles and the Banff grading of fibrosis.

Conclusions
Renal stiffness quantified by 2D SWE showed significant correlation with histopathological renal fibrosis. Thus, the study suggests that shear-wave elastography could be used as a surrogate marker for early detection of renal fibrosis.