ISSN: 1899-0967
Polish Journal of Radiology
Established by prof. Zygmunt Grudziński in 1926 Sun
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vol. 88
Urogenital radiology
Original paper

68Ga-PSMA PET-CT and PSMA score affecting therapeutic decision-making in high-risk prostatic carcinoma

Tahira Yasmin
Muhammad Numair Younis
Khalid Ameer
Ahmed Farooq
Abubaker Shahid

Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistan
Department of Orthopaedics, District Headquarter (DHQ) Hospital, Chakwal, Punjab, Pakistan
© Pol J Radiol 2023; 88: e331-e337
Online publish date: 2023/07/17
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This research study was conducted to evaluate the impact of (68Ga)-tagged prostatic-specific membrane antigen (68Ga-PSMA) positron emission tomography and computed tomography (PET-CT), compare its role with conventional radiology in early staging of high-risk prostate cancer, and calculate the PSMA score evaluating its usefulness in 68Ga-PSMA PET-CT reporting in our patient population.

Material and methods:
68Ga-PSMA PET-CT of 65 high-risk cases of prostate cancer was performed for staging purpo­ses. Any change in disease stage was noted after 68Ga-PSMA PET-CT findings and PSMA score leading to a change in the management plan.

Change in disease stage post-PSMA imaging was seen in 39% cases, high PSMA score (03) was noted in > 80% of upstaged cases, while low score (0) and (1) was seen in 65% and 35% down-staged individuals, respectively. Change in therapeutic decision-making was observed in 32% (21) of patients.

68Ga-PSMA PET-CT scans have a significant influence on the planned clinical management of high-risk prostate cancer patients; hence, they can be utilized as a replacement for radiological imaging tools, particularly in the detection of pelvic nodal and distant metastatic disease. PSMA score can be considered as an effective tool in standardized reporting of 68Ga-PSMA imaging.


radiologic imaging, 68Ga-PSMA PET-CT, PSMA score, therapeutic decision-making

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