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1/2023
vol. 88 Gastrointestinal and abdominal radiology
abstract:
Original paper
Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
Joanna Podgórska
1, 2
,
Katarzyna Pasicz
3
,
Witold Skrzyński
3
,
Bogumił Gołębiewski
2
,
Piotr Kuś
2
,
Jakub Jasieniak
2
,
Agnieszka Rogowska
4, 5
,
Paweł Kukołowicz
3
,
Andrzej Cieszanowski
1, 2
1.
2nd Department of Clinical Radiology, Warsaw Medical University, Poland
2.
Department of Radiology 1, the Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
3.
Department of Medical Physics, the Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
4.
Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland
5.
Department of Oncological Gastroenterology, the Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
© Pol J Radiol 2023; 88: e455-e460
Online publish date: 2023/10/04
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Purpose:
Diffusion kurtosis imaging (DKI) is an MRI method related to diffusion imaging (DWI) that is distinguished by a non-Gaussian calculation of water particles movements in tissues. The aim of the study was to assess DKI advantage over DWI in differentiating benign and malignant liver lesions. Material and methods: Analysis included prospectively acquired group of 83 patients referred consecutively for 3T-MRI liver tumor examination, with 95 liver lesions (31 benign, 59 malignant). MRI assessments were performed with standard protocol and DKI sequence with seven b-values (0-2,000 s/mm2). Quantitative data were acquired by placing ROIs in liver tumors on all b-value images, ROI data extracted, and calculation of DWI and DKI parameters. ADC was calculated for all b-values (ADC0-2000) and for three values of b = 0, 500, and 750 (s/mm2) (ADC0-500-750). DKI and ADC parameters for benign and malignant lesions were compared, and ROC curves were plotted. Results: Significant differences were obtained for all DKI and ADC parameters. ROC analysis showed AUC of DK, K, ADC0-2000, and ADC0-500-750 was 0.74, 0.77, 0.77, and 0.75, respectively. The highest sensitivity (of 0.91) was obtained for ADC0-2000. The highest specificity (0.65) and accuracy (0.80) was obtained for K. Conclusions: DKI technique yields statistically comparable results with DWI technique. keywords:
MRI, diffusion kurtosis imaging (DKI), diffusion weighted imaging (DWI), liver tumor |
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