CARDIOVASCULAR RADIOLOGY / ORIGINAL PAPER
Chronic thromboembolic hypertension predictors in computed tomography angiography. Single-centre study
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1
1st Department of Clinical Radiology, Medical University of Warsaw, Poland
2
Department of Internal Medicine and Cardiology with the Centre for Diagnosis and Treatment of Venous Thromboembolism, Medical University of Warsaw, Poland
Submission date: 2025-03-29
Final revision date: 2025-04-13
Acceptance date: 2025-04-18
Publication date: 2025-05-29
Corresponding author
Konstantin Szewczuk
1st Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland
Pol J Radiol, 2025; 90: 267-278
KEYWORDS
TOPICS
ABSTRACT
Purpose:
Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening but curable form of pulmonary hypertension. Early diagnosis is crucial for effective management and improved outcomes. Computed tomography pulmonary angiography (CTPA), characterised by high sensitivity and specificity, is integral to diagnosing CTEPH by identifying thrombi and associated pulmonary and mediastinal abnormalities. However, radiological features often overlap with other diseases, and their detection depends on radiologist expertise. This study aims to assess the frequency of characteristic radiological features in CTEPH, compare their prevalence with chronic thromboembolic disease (CTED), pulmonary arterial hypertension (PAH), and acute pulmonary embolism (APE), and evaluate their diagnostic predictive value.
Material and methods:
This retrospective study analysed 115 patients divided into CTEPH (n = 35), CTED (n = 20), PAH (n = 24), and APE (n = 36) groups, matched by age and sex. CTPA scans were reviewed for signs of chronic embolism, pulmonary hypertension, and right heart overload. Sensitivity, specificity, accuracy, and predictive values were assessed using ROC analysis, expressed as the area under the curve (AUC).
Results:
CTEPH patients exhibited vessel narrowing, intimal irregularities, bands, and webs in all cases (100%), with the highest diagnostic value at the segmental level (AUC = 0.906). Mosaic perfusion and variability in vessel size demonstrated moderate predictive value (AUC = 0.740 and AUC = 0.788, respectively).
Conclusions:
CTPA is essential for differentiating CTEPH from other pulmonary vascular conditions. While no single feature achieves 100% predictive value, a comprehensive approach integrating vascular, parenchymal, and cardiac findings is critical for accurate diagnosis.
REFERENCES (30)
1.
Ruaro B, Baratella E, Caforio G, Confalonieri P, Wade B, Marrocchio C, et al. Chronic thromboembolic pulmonary hypertension: an update. Diagnostics (Basel) 2022; 12: 235. DOI: 10.3390/diagnostics12020235.
2.
Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al.; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2023; 61: 2200879. DOI: 10.1183/13993003.00879-2022.
3.
Fathala A, Aldurabi A. Frequency of computed tomography abnormalities in patients with chronic thromboembolic pulmonary hypertension: a comparative study between lung perfusion scan and computed tomography pulmonary angiography. Multidiscip Respir Med 2021; 16: 753. DOI: 10.4081/mrm.2021.753.
4.
Gopalan D, Delcroix M, Held M. Diagnosis of chronic thromboembolic pulmonary hypertension. Eur Respir Rev 2017; 26: 160108. DOI: 10.1183/16000617.0108-2016.
5.
Zhang Y, Yu X, Jin Q, Luo Q, Zhao Z, Zhao Q, et al. Advances in targeted therapy for chronic thromboembolic pulmonary hypertension. Heart Fail Rev 2019; 24: 949-965.
6.
Gopalan D, Blanchard D, Auger WR. Diagnostic evaluation of chronic thromboembolic pulmonary hypertension. Ann Am Thorac Soc 2016; 13 Suppl 3: S222-S239. DOI: 10.1513/AnnalsATS.201509-623AS.
7.
Ciurzyński M, Kurzyna M, Kopeć G, Błaszczak P, Chrzanowski Ł, Kamiński K, et al. An expert opinion of the Polish Cardiac Society Working Group on Pulmonary Circulation on screening for chronic thromboembolic pulmonary hypertension patients after acute pulmonary embolism: update. Kardiol Pol 2022; 80: 723-732.
8.
Castañer E, Gallardo X, Ballesteros E, Andreu M, Pallardó Y, Mata JM, et al. CT diagnosis of chronic pulmonary thromboembolism. Radiographics 2009; 29: 31-50; discussion 50-53.
9.
Willemink MJ, van Es HW, Koobs L, Morshuis WJ, Snijder RJ, van Heesewijk JP. CT evaluation of chronic thromboembolic pulmonary hypertension. Clin Radiol 2012; 67: 277-285.
10.
Nishiyama KH, Saboo SS, Tanabe Y, Jasinowodolinski D, Landay MJ, Kay FU. Chronic pulmonary embolism: diagnosis. Cardiovasc Diagn Ther 2018; 8: 253-271.
11.
Rogberg AN, Gopalan D, Westerlund E, Lindholm P. Do radiologists detect chronic thromboembolic disease on computed tomography? Acta Radiol 2019; 60: 1576-1583.
12.
Wittram C, Kalra MK, Maher MM, Greenfield A, McLoud TC, Shepard JA. Acute and chronic pulmonary emboli: angiography-CT correlation. AJR Am J Roentgenol 2006; 186 (6 Suppl 2): S421-S429. DOI: 10.2214/AJR.04.1955.
13.
Lambert L, Michalek P, Burgetova A. The diagnostic performance of CT pulmonary angiography in the detection of chronic thromboembolic pulmonary hypertension-systematic review and meta-analysis. Eur Radiol 2022; 32: 7927-7935.
14.
Grosse A, Grosse C, Lang IM. Distinguishing chronic thromboembolic pulmonary hypertension from other causes of pulmonary hypertension using CT. AJR Am J Roentgenol 2017; 209: 1228-1238.
15.
Capone C, Valentini A, Spinillo SL, Klersy C, Celentano A, Pin M, et al. Radiological differences between chronic thromboembolic pulmonary disease (CTEPD) and chronic thromboembolic pulmonary hypertension (CTEPH). Eur Radiol 2021; 31: 6230-6238.
16.
Ende-Verhaar YM, Meijboom LJ, Kroft LJM, Beenen LFM, Boon GJAM, Middeldorp S, et al. Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study. J Heart Lung Transplant 2019; 38: 731-738.
17.
Auger WR, Fedullo PF, Moser KM, Buchbinder M, Peterson KL. Chronic major-vessel thromboembolic pulmonary artery obstruction: appearance at angiography. Radiology 1992; 182: 393-398.
18.
McInnis MC, Wang D, Donahoe L, Granton J, Thenganatt J, Tan K, et al. Importance of computed tomography in defining segmental disease in chronic thromboembolic pulmonary hypertension. ERJ Open Res 2020; 6: 00461-2020. DOI: 10.1183/23120541.00461-2020.
19.
King MA, Bergin CJ, Yeung DW, Belezzouli EE, Olson LK, Ashburn WL, et al. Chronic pulmonary thromboembolism: detection of regional hypoperfusion with CT. Radiology 1994; 191: 359-363.
20.
Bergin CJ, Rios G, King MA, Belezzuoli E, Luna J, Auger WR. Accuracy of high-resolution CT in identifying chronic pulmonary thromboembolic disease. AJR Am J Roentgenol 1996; 166: 1371-1377.
21.
Endrys J, Hayat N, Cherian G. Comparison of bronchopulmonary collaterals and collateral blood flow in patients with chronic thromboembolic and primary pulmonary hypertension. Heart 1997; 78: 171-176.
22.
Ley S, Kreitner KF, Morgenstern I, Thelen M, Kauczor HU. Bronchopulmonary shunts in patients with chronic thromboembolic pulmonary hypertension: evaluation with helical CT and MR imaging. AJR Am J Roentgenol 2002; 179: 1209-1215.
23.
Remy-Jardin M, Duhamel A, Deken V, Bouaziz N, Dumont P, Remy J. Systemic collateral supply in patients with chronic thromboembolic and primary pulmonary hypertension: assessment with multi-detector row helical CT angiography. Radiology 2005; 235: 274-281.
24.
van der Bijl N, Klok FA, Huisman MV, van Rooden JK, Mertens BJA, de Roos A, et al. Measurement of right and left ventricular function by ECG-synchronized CT scanning in patients with acute pulmonary embolism: usefulness for predicting short-term outcome. Chest 2011; 140: 1008-1015.
25.
Ng CS, Wells AU, Padley SP. A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter. J Thorac Imaging 1999; 14: 270-278.
26.
Chan AL, Juarez MM, Shelton DK, MacDonald T, Li CS, Lin TC, et al. Novel computed tomographic chest metrics to detect pulmonary hypertension. BMC Med Imaging 2011; 11: 7. DOI: 10.1186/1471-2342-11-7.
27.
Cummings KW, Bhalla S. Multidetector computed tomographic pulmonary angiography: beyond acute pulmonary embolism. Radiol Clin North Am 2010; 48: 51-65.
28.
King MA, Ysrael M, Bergin CJ. Chronic thromboembolic pulmonary hypertension: CT findings. AJR Am J Roentgenol 1998; 170: 955-960.
29.
Baque-Juston MC, Wells AU, Hansell DM. Pericardial thickening or effusion in patients with pulmonary artery hypertension: a CT study. AJR Am J Roentgenol 1999; 172: 361-364.
30.
Raymond RJ, Hinderliter AL, Willis PW, Ralph D, Caldwell EJ, Williams W, et al. Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. J Am Coll Cardiol 2002; 39: 1214-1219.